KMID : 0043320110340122029
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Archives of Pharmacal Research 2011 Volume.34 No. 12 p.2029 ~ p.2035
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Lignans from the flowers of Osmanthus fragrans var. aurantiacus and their inhibition effect on NO production
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Lee Do-Gyeong
Lee Sang-Min Bang Myun-Ho Park Hee-Jung Lee Tae-Hoon Kim Yun-Hee Kim Ji-Young Baek Nam-In
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Abstract
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A new lignan, (7R,7¡ÇR,8R,8¡ÇR)-8-hydroxypinoresinol 8-O-¥â-D-glucopyranoside 4¡Ç-methyl ether (7), was isolated from the flowers of Osmanthus fragrans var. aurantiacus along with six known lignans: (+)-phillygenin (1), phillyrin (2), (?)-phillygenin (3), (?)-epipinoresinol-¥â-D-glucoside (4), taxiresinol (5), and (?)-olivil (6). The structure of the new compound was elucidated on the basis of 1D- and 2D-NMR spectroscopic analysis and specific rotation data. The compounds isolated from the flowers of O. fragrans var. aurantiacus were evaluated for inhibitory activities on nitric oxide production in lipopolysaccharide-stimulated macrophage RAW 264.7 cells. (+)-Phillygenin (1), phillyrin (2), and (?)-phillygenin (3) exerted the strongest inhibitory activities on NO production with IC50 values of 25.5, 18.9, and 25.5 ¥ìM, respectively. These compounds may prove beneficial in the development of natural agents for prevention and treatment of inflammatory diseases.
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KEYWORD
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Anti-inflammation, Lignan, Nitric oxide, Osmanthus fragrans var. aurantiacus, (7R, 7¡ÇR, 8R, 8¡ÇR)-8-Hydroxypinoresinol 8-O-¥â-D-glucopyranoside 4¡Ç-methyl ether
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